Multiple lines of evidence indicate that complex multicellularity evolved at least six different times. which of the superkingdoms includes organisms that exhibit complex multicellularity?

Answers

Answer 1

Opisthokonta, Archaeplastida, Stramenopila from the superkingdoms includes organisms that exhibit complex multicellularity.

Complex multicellularity appeared comparatively late in life's history, in the Ediacaran Period, more than three billion years after microbial life began to diversify. Plants, animals, and macroscopic fungus form terrestrial landscapes, while creatures and seaweeds animate the water. Complex multicellularity is the most sophisticated degree of biological structure and has only occurred a few times in metazoans, green plants, brown and red algae, and fungus. Opisthokonta, Archaeplastida, and Stramenopila are the superkingdoms with creatures that display complex multicellularity. Opisthokonts are eukaryotic groupings that comprise amoebae, fungi, and mammals. The photoautotrophic red algae, green algae, land plants, and the small group glaucophytes comprise the Archaeplastida, a large group of eukaryotes. Stramenopiles are eukaryotes categorized as protists because they are not fungi, animals, or plants.

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Related Questions

The nipple is located near the tip of each breast at about the level of the ______ and it is surrounded by a circular area of pigmented skin called ______.

Answers

The nipple is about the level of the lobe and it is surrounded by a circular region of pigmented skin called areola.

Both female and male sexual anatomy include breasts. Breasts are both functional for lactation and sexual organs in females (bringing pleasure). Male breasts serve no purpose. The nipples and areolae are among the breast anatomy that may be seen. The nipple, areola, nerves, mammary gland, and other structures are among the many parts of the breast.

In females, milk exits the breast through the lactiferous ducts from the nipple, a raised area of tissue on the breast's surface, to feed an infant. Milk may passively flow through the nipple or may be expelled by the ductal system's smooth muscle contractions. The areola, which frequently has a darker hue than the surrounding skin, surrounds the nipple.

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During which event of hemostasis do clotting factors (procoagulants) assist with the transformation of blood from a liquid to a gel?

Answers

coagulation stage

During coagulation stage of hemostasis do clotting factors (procoagulants) assist with the transformation of blood from a liquid to a gel.

Blood clots are created when blood coagulates, or turns from a liquid to a gel. Hemostasis, the halting of blood loss from a damaged vessel, may ensue, followed by repair.Platelets are directed to the location of the damage, while normal blood flow is kept in the uninjured parts, limiting coagulation to the affected tissue.Platelet activation, adhesion, and aggregation as well as fibrin deposition and maturation are all components of the coagulation mechanism.

What are the two fundamental steps in the coagulation of blood?The intrinsic and extrinsic routes, which are two distinct but interconnected pathways, play a role in the clotting cascade. External trauma that causes blood to escape from the vascular system activates the extrinsic route. Compared to the intrinsic pathway, this pathway is faster.

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Sweet potatoes ipomoea batatas are hexaploid with 90 chromosomes. (6n = 90). how many telomeres would you expect to find in a sweet potato cell in g1?

Answers

Sweet potatoes Ipomoea batatas are hexaploid with 90 chromosomes. (6n = 90).Then they will have 360 telomeres in the G1 phase of the cell.

Chromosomes are the compact form of genetic material. It consists of proteins and DNA that are wound together to form this compact structure. A chromosome consists of two sister chromatids that are joined together by a protein called kinetochore and the point of junction is called the centromere. Each sister chromatid has 2 telomeres and therefore, one chromosome has total 4 chromosomes.

G1 phase of the cell cycle is the one where the cell prepares for the nuclear formation. It synthesizes various mRNA and proteins that are required in the S phase of the cell cycle. There is no change in the number of chromosomes during this phase and hence the number of telomeres will remain 360.

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ASAP Please Help

The rate of photosynthesis can be measured as the volume of oxygen released by a
plant per minute. The number of bubbles of gas released per minute from waterweed is
counted.

a. The gas collected in this experiment is not pure oxygen. Suggest a reason for this.

Answers

Answer:

The gas will be released.

Explanation:

In this experiment the solution used is sodium bicarbonate to increase the CO2 content for photosynthesis process.

So the gas released will not be only pure oxygen but also CO2 which is provided by the sodium bicarbonate solution.

A nerve impulse moves toward a neuron's cell body along _____. a nerve impulse moves toward a neuron's cell body along _____. dendrites synaptic terminals oligodendrocytes axons nodes of ranvier

Answers

A nerve impulse moves toward a neuron's cell body along dendrites.

A nerve impulse is an electrical charge that is generated as a result of any stimuli that travel along the neuron membrane and is also called an action potential.

The nervous system consists of neurons which are also known as nerve cells that receive sensory signals from the external environment and integrate the input signals and then relay these signals to the target cells and organs. Sensory, motor, and interneurons are the three main types of neurons present in human beings.

Neurons are made up of three main parts which are dendrites, axons, and cell body. The cell body is also called soma.

Dendrites are the receiving part of the neuron and carry the impulses to the cell body by receiving inputs from the axon.

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most prokaryotic cells reside most prokaryotic cells reside in and on nonprokaryotic organisms (including humans and other animals). on earth's surface. in the oceanic and terrestrial subsurfaces. in lakes, rivers, and oceans.

Answers

Most prokaryotic cell reside in the oceanic and terrestrial sub surfaces. These prokaryotic organisms are single celled organism that does not have a nucleus like bacteria.

These organisms fed on the carbon compounds that is accumulating in earths early oceans. These organisms does not contains genetic material in nucleus. The DNA exists in the region of cell that is called as nucleoid.

These organisms have a rapid reproductive rate and also have a ability to survive harsh conditions.

Nucleoid is an irregular shaped region that is present in the prokaryotic cell  and these contain genetic material.

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The basic structure of the plasma membrane is a diverse collection of proteins floating within a lipid framework, which is often referred to as the ______.

Answers

Fluid mosaic model

The basic structure of the plasma membrane is a diverse collection of proteins floating within a lipid framework, which is often referred to as the fluid mosaic model.

Describe the fluid mosaic model.Phospholipids, cholesterol, and proteins are only a handful of the substances that are constantly flowing through the cell membrane, according to the fluid mosaic theory. This movement helps the cell membrane preserve its function as a partition separating the cell's internal and external surroundings.

What are the fluid mosaic model's primary components?The creators of the fluid mosaic model are S.J. Singer and Garth L. Nicolson. According to this hypothesis, the plasma membrane of animal cells is made up of a patchwork of substances, including phospholipids, proteins, cholesterol, and carbohydrates. The fluidity of the membranes is due to these components.

What makes the fluid mosaic model mosaic?

Due to the following characteristics of cell membranes, which are depicted using a fluid-mosaic model:

The phospholipid bilayer is fluid; each phospholipid can move around in its place.When proteins are implanted in the phospholipid bilayer, a mosaic of components is produced.

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What is the phenotypic ratio of the offspring?

Answers

Answer:

The phenotypic ratio is the distribution pattern (expressed as a ratio) of the physical characteristics in the offspring obtained after a genetic cross.

HOPE IT'S HELPS YOU

list precautions used in the science laboratory to minimize the following risks
a) poisoning
b) scalding
c) eye damage

Answers

Answer:

Avoid skin and eye contact with all chemicals.

Minimize all chemical exposures.

Know locations of laboratory safety showers, eyewash stations, and fire extinguishers.

Assume that all chemicals of unknown toxicity are highly toxic.

Explanation:

A bacterium engulfed by a white blood cell through phagocytosis will be digested by enzymes contained in _____.
a) vacuoles secretory
b) vesicles lysosomes
c) golgi vesicles

Answers

A bacterium engulfed by a white blood cell through phagocytosis will be digested by enzymes contained in vacuoles secretory (option A).

What is phagocytosis?

Phagocytosis is the form of endocytosis in which a cell incorporates a particle by drawing the particle into a vacuole of its cytoplasm.

The white blood cell, also known as the leucocytes are the defense of the body as they help fight against foreign substances which they attack by phagocytosis.

Since the foreign bodies are pulled into the vacuole, hence, it can be said that bacterium engulfed by a white blood cell through phagocytosis will be digested by enzymes contained in vacuoles secretory.

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Experiments involving the cloning of toxin molecules with ld50 < 100 ng/kg fall under which category of experiments?

Answers

Experiments involving the cloning of toxin molecules with LD50 < 100 ng/kg fall under the category of experiments that require NIH OSP and IBC approval before initiation.

In LD50, the LD stands for Lethal Dose. It determines the amount of chemical/toxin required to kill the 50 % organisms of the total population. This is used to measure the acute toxicity of any material. The unit for measure of DD50 is milligrams of chemical per kilogram of body weight.

NIH is the National Institute of Health. It is inclined towards the research upon medical and behavioral aspects. The aim of conducting such researches is to reduce the diseases and increase wellness in the society.

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When biological molecules engage in condensation, such reactions are _________ reactions.

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synthesis

When biological molecules engage in condensation, such reactions are synthesis reactions.

A huge number of monomers coming together to form a large macromolecule is what is known as a polymerization reaction. During the process, a tiny molecule like water is liberated.The new molecule is created by joining the single monomer unit. Due to the fact that a new molecule is created during this reaction, it is also known as the synthesis reaction. The synthesis reaction also results in the synthesis of biomolecules.

Condensation in a biological reaction: what is it?Any of a series of reactions known as condensation reactions occurs when two molecules join, typically with the help of a catalyst, and water or another simple molecule is eliminated. Self-condensation is the joining of two identical molecules.

Which are the four major biomolecules?Any of the various compounds created by cells and living things is referred to as a biomolecule, sometimes known as a biological molecule. Biomolecules come in a wide variety of shapes and sizes and serve a wide range of purposes. Proteins, lipids, nucleic acids, and carbohydrates are the four main categories of biomolecules.

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6. bears were once present as far south as california. over time they have disappeared
in most of the lower 48 states. how might the influx of humans have influenced bear
populations?

Answers

Bears were once present as far south as California. Over time they have disappeared in most of the lower 48 states.

Human have influenced bear populations as they are a factor of resource competition for the bear species, due to the fact that the resource available in the environment have value to both humans and bears. Major changes in disturbance cycles and landscape mosaics brought by humans have further affected temporal and spatial pulses of bear food production. Air pollution has also affected bear food biomass on a small scale and is likely to have major future impacts on bear habitat climatic warming.

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What is a period in the periodic table?
The vertical column of elements
Each element
The horizontal row of elements
The particles of similar atoms

Answers

A period in the periodic table is the horizontal row of elements (option C).

What is a periodic table?

The periodic table is a tabular chart of the chemical elements according to their atomic numbers so that elements with similar properties are in the same group (column).

The periodic table arranges chemical elements into groups and periods. The vertical column is called the groups while the horizontal rows are called the periods.

In the periodic table, there are 7 periods and 18 groups that encompass the chemical elements.

Therefore, a period in the periodic table is the horizontal row of elements.

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A(n) ____________________ is a sequence of organic nitrogen base pairs that codes for a polypeptide or a protein.

Answers

A(n) gene is a sequence of organic nitrogen base pairs that codes for a polypeptide or a protein.

What is polypeptide?

Peptides are made up of short chains of amino acids joined together by peptide bonds. The word "peptide" comes from the Ancient Greek word "peptós," which means "digested." Oligopeptides, which comprise dipeptides, tripeptides, and tetrapeptides, are chains of fewer than twenty amino acids.

A polypeptide is a peptide chain that is longer, continuous, and unbranched.

 Therefore, along with nucleic acids, oligosaccharides, polysaccharides, and others, peptides belong to the large chemical families of biological polymers and oligomers.

A protein is a polypeptide that has more than 50 amino acids, on average. A protein is made up of one or more polypeptides that are structured in a biologically useful manner. Proteins are frequently coupled to other proteins, other macromolecules like DNA or RNA, or complex macromolecular assemblies.

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What possible uses do computerized devices have in optometry?

Answers

Coputerized devices are used to detect glaucoma, precise the cataract procedure and check for retinal tears.

What are the tools used by optometrists?

Regular people may find the tools used by optometrists daunting, which is why many avoid or persistently put off getting their yearly eye exams. However, these tools are quick, effective, and incredibly accurate at determining the condition of the eye.

The common instruments used by ophthalmologists and optometrists to perform eye exams are listed below.

TonometerPhoropterRetinoscopeAutorefractorSnellen ChartRetinal CameraOphthalmoscopeVT 1 Vision Screener

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How is/are the relevant variable(s) of fick's law optimized by the countercurrent oxygen exchange in lugworm gills?

Answers

(P high - P low) is re-established to optimize the variable(s) of Fick's law.

According to Fick's law of diffusion, particles subject to random thermal motion have a tendency to move from an area of higher concentration to an area of lower concentration. Fick's diffusion law, which asserts that the diffusion flow is proportional to the concentration gradient, mathematically describes three-dimensional diffusion.

The diffusion process is explained by Fick's law of diffusion (movement of molecules from higher concentration to lower concentration region). Adolf Fick first explained Fick's Law of Diffusion in 1855. Normal diffusion, often known as Fickian diffusion, is a diffusion process that complies with Fick's rules. An abnormal diffusion process also referred to as non-Fickian diffusion, defies Fick's rules.

According to Fick’s law of diffusion,

“The molar flux due to diffusion is proportional to the concentration gradient”.


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For men, what is the average portion size of protein dense foods with each meal?

Answers

two palm-sized portions

The average portion size of protein dense foods with each meal two palm-sized portions.

Use a serving the size of your palm for foods high in protein, such as meat, fish, eggs, dairy, or legumes. With each meal, we advise guys to eat two palm-sized portions. In addition, we advise women to have one palm-sized quantity with each meal.

Why is it crucial to have physical fitness objectives?Your route to wellbeing must include fitness goals. Setting objectives can help you push through the most challenging times to make a change that will stay longer, hold yourself more accountable, and demonstrate to yourself what you are capable of.

What foods contain the most protein?

proteins in foods

Kangaroo, beef, lamb, veal, and other lean meats.Birds of the bush, include chicken, turkey, duck, emu, and duck.prawns, crab, lobster, mussels, oysters, scallops, clams, and fish are all examples of seafood.eggs.dairy items, such as milk, cheese, and yoghurt (particularly Greek yoghurt) (especially cottage cheese)

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When using a wet mount on a brightfield microscope, what could you add to your specimen?

Answers

In a wet mount, the specimen is held in place between the slide and cover slip by a drop of water. On the slide, place a sample. Put a drop of water on the sample with a pipette. Place the cover slip's edge over the sample and slowly drop it into position using a toothpick or something similar.

What kind of solution should be prepared a moist mount?

Wet mounts may be created using a variety of substances. You may use water, immersion oil, and glycerin (glycerol), with water likely being the most popular.

In a wet mount, a little drop of water is applied to the slide, and the specimen is covered with a cover slip to preserve it.

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lesson of the kaibab hypothesis?

Answers

Relationships between organisms and their physical surroundings as well as forces inside the biotic community have the potential to change the environment. The maximum number of creatures that a region can sustainably support is known as an ecosystem's carrying capacity. When a population is dense, the habitat may undergo such significant changes that the ecosystem is no longer suited for the survival of that species. For instance, excessive grazing on a piece of land may prevent it from supporting the grazing of the animals inhabited there.

Predators were eliminated and the forest service outlawed hunting.According to the graph, by 1924, the population had gotten out of hand; 100,000 people were living on a plateau with a carrying capacity of 30,000.Because the deer destroyed their habitat, there were 100,000 deer where there should have only been 30,000, which caused the population to fall.Due to natural predators and legal hunting, the deer population was much below its carrying capacity.The deer were unable to survive on the range after hunting was once more permitted. Food was scarce, and the populace was too frail to procreate.

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An example of _________ correlation would be the more a mother smokes, the more damage a fetus suffers.

Answers

Positive

An example of positive correlation would be the more a mother smokes, the more damage a fetus suffers.

What is a positive correlation?A positive correlation is defined as the tendency of two variables to move in the same direction.When one variable tends to go down as the other goes down or when one variable tends to go up as the other goes up, there is a positive correlation.

How can you tell if a correlation is favorable?The correlation coefficient is calculated on a scale from + 1 to -1.Either + 1 or -1 represents a variable's complete connection with another. When one variable declines as the other grows, the correlation is negative; when both variables increase , it is positive.

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Different chemical elements will create a different scattering of absorption lines in the spectrum of visible light. We understand the interaction of an atom with light, and because of this we can predict where the lines should be and verify this in a lab. This process is called?

A. Astronomy
b.Nucleosynthesis
c.Spectroscopy
d. Star formation

Answers

Chemists research the interactions of many types of electromagnetic radiation with atoms and molecules. The term "spectroscopy" refers to this interaction.

Because various elements have varying quantities of protons and varied numbers and configurations of electrons, they also have different spectra. The variations in spectra are a result of the energy that atoms absorb or emit as their electrons shift between different energy levels. A transition from ground state or lower-energy excited state to a greater excited state can occur as a result of an atom's ability to absorb light of a certain energy. As a result, an element's emission spectrum is converted into an absorption spectrum, which contains dark lines aligned with brilliant lines. Chemists research the interactions of many types of electromagnetic radiation with atoms and molecules. The term "spectroscopy" refers to this interaction. Ordinary stars like the Sun have absorption lines in their spectra because some of the continuous light emanating from the hot, dense interior is absorbed by the fragile outer layers of the stellar atmosphere, known as the photosphere.

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Which cytoskeletal structures may be linked to an inability to contract and relax the muscle?

Answers

The cytoskeletal structure linked to an inability to contract and relax the muscle is actin.

What's a cytoskeleton?

Network of fibres that form the framework or infrastructure of most animal cells are called cytoskeletons. They consist of a complex network of proteins that help in cell movement and stabilize the cell.

What is Actin?

Actin is a globular, multifunctional protein found in the myofibril of muscle tissues of all eukaryotic cells. Actin takes part in many cellular functions like cell division, cytokinesis, cell mobility and establishment of cell shape. Most importantly, it is necessary for muscular contraction.

Infection, inflammation and mutations in the genes that regulate the production of actin leads to an inability to contract and relax the muscle.

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The observable expression of one's genetic makeup is referred to as his or her _________.

Answers

To as his or her •Phenotype•

. About how long ago did Archimedes live?
A. 2,260 years ago
B. 2,000 years ago
C. 250 years ago
D. 2,000,000 years ago

Answers

It’s the first one A

How much rotation of the body is required for the posterior axial oblique projection for acetablulm?

Answers

The posterior oblique (Judet method) for the acetabulum requires a 10- to 15-degree rotation of the body.

What is acetablulm ?

The acetabulum is the hip joint's socket. Types of acetabular fractures are categorised based on pattern and severity. Acetabular fractures are distressing wounds that typically call for surgery. The cartilage that encircles your hip socket might cause complications like hip arthritis.

The three bones that make up our hip are together to form the acetabulum, which resembles a cup. The hip joint is created when the femoral head of the femur bone fits into this socket. We can walk, run, and move about freely thanks to these two anatomy components working together.

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The molecules activated by light in photoreceptors are called:_______
a. the sclera
b. the na/ca exchanger
c. rhodopsin
d. the voltage gated sodium channels
e. guanylyl cyclase

Answers

The molecules activated by light in photoreceptors are called rhodopsin

Photoreceptors are the cells in the retina that are specialized to respond to the light ans are called visual photo-transduction. They function is to convert the light into stimuli which can be processed by our brain.

They absorb the photons and causes a change in the cell membrane potential. They are of three types- rodes, cones and intrinsically photosensitive retinol ganglion cells.

Rods are more sensitive and are used in low light vision while cons are used in bright light vision.

Rods contain a photosensitive pigment called rhodopsin which is extremely sensitive to light. it is activated by even dim light.

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Infancy is a sensitive period in terms of brain development especially due to _____________________

Answers

Infancy is a sensitive period in terms of brain development especially due to its ability to adapt and learn from experiences.

Sensitive periods are the period in which an individual is more sensitive to various experiences and environments. He learns from his experiences and makes himself adapt to the environment. It occurs during prenatal and postnatal periods when development generally occurs slower. For example, a child learns his native language slowly while living in an environment and learns more experiences.

Sensitive periods in terms of brain development are when synapses and their neural routes are created earlier than other times. The formation of synapses and neural pathways is termed synaptogenesis. During this period, the brain prepares itself to learn from experiences and adapt itself to the environment.

An infant when exposed to a certain type of environment would develop his skills and intelligence accordingly. This is why it is often referred to as the sensitive period of development.

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A hypothesis may be considered what?

Answers

Answer:

a tentative, testable explanation

Explanation:

Answer:

A hypothesis is a testable assumption/prediction that you make based on some basic evidence. It is the starting point for further investigation.

Explanation:

:D

PLEASE HELP


1.Alex poured some pond water into three beakers. She then put waterweed into each

beaker. She put the beakers in different places.


i) In which beaker did the waterweed grow best? Give the correct letter.

________

ii) The waterweed in the box changed from dark green to pale yellow. Why did this happen?

2.In the school pond there were lots of water lilies with large leaves covering the surface. There were not many plants growing below the surface. Suggest a reason
for this.

3.In another experiment, Alex put similar pieces of waterweed into two more beakers of pond water. She added fertiliser to one of them. She kept them both by a window.

i) Alex added fertiliser to beaker E. Suggest the results of this experiment.
ii) What do fertilisers contain to help plants grow? Tick the correct box.

Answers

I think 1, 2, and 3 were already answered so I'm going to answered the other ones.

3i. The results of this experiment to development a plant which is NPK. So it results of the fertilizers needing a plant development of nitrogen, phosphorous, and potassium.

3ii. Fertilizers contain "minerals." Minerals are responsible for growth and development of a plant. They also contain nitrogen, phosphorous, and potassium. Nitrogen - Main component of chlorophyll, Enzymes. Phosphorous - Vital component of ATP. Potassium - Important for enzyme activation and transport of water.

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Which folder will automatically upload a file saved in it to your onedrive account? The potential at points a and b are: va = -2 v and vb = 6 v. when a 5 c charge is moved from a to b, the change in potential energy of this system is answer j. What was (were) the major influence(s) of the 1960s that increased the need for trained human services professionals? Convert the following temperatures.a. 75 K to degrees Fahrenheitb. 96F to degrees Celsius in the late nineteenth century, immigrants from which two countries were the largest groups to move to the united states? choose exactly two answers that are correct. germany germany russia russia italy italy ireland ireland Starting with fructose 6-phosphate and proceeding to pyruvate, what is the net yield of atp molecules? A clinic nurse notes that large numbers of clients present with flu-like symptoms. which recommendations should the nurse include in the plan of care for these clients? select all that apply. Study the cartoon by james silk. how do the ice float and the text create meaning? What did king george do to english colonists in the new world that violated the principles of the magna carta?. Exercise 2 Correct the word in italics. If the word is correct, write C.George Foreman lost to Muhammad Ali in 1974; then twenty years later he beat Michael Moorer to regain the heavyweight championship. Find the least numbers which must be subtracted from the following number to make them perfect square 42029 Use the paragraph to answer the question.The red velvet ant is famous for having one of the most painful stings in the insect world. In fact, it is often called the cow killer ant, because its sting is said to be so terrible it could kill a cow. Neither one of these names perfectly suit the creature, because it is actually not an ant at all. The red velvet ant is a flightless wasp that usually takes over the nests of bumble bees and stays low to the ground. Only the female of the species has a stinger, but what a stinger it is! It is exceptionally large and packs one serious punch. While the sting is not deadly, save for those who might have an allergic reaction, it is a highly unpleasant sensory experience.What evidence would cause a person fear the red velvet ant?It takes over bee nests.It lives on the ground.It has a powerful stinger.It is flightless. The deeds of mercy. I have spoke thus much 3.1. Place this extract in context. 3.2. Refer to line 1: 'I am informed thoroughly of the cause.' Explain the 'cause' that Portia makes reference to in this line. 3.3. Refer to line 13: 'Then must the Jew be merciful.' Account for Portia's request in this line. 3.4. Refer to line 14: 'On what compulsion must I? Tell me that.' Critically comment on what the above line reveals about Shyloc 3.5. Refer to lines 15-16: 'The quality of mercy... rain from Heaven" Discuss how the imagery in these lines coveys Portia's tone. 3.6. Critically evaluate the punishment that is metered out to Shylock On the scene of a multiple-casualty incident, you note that another emt has become overwhelmed and emotionally incapacitated after unsuccessfully trying to save a child's life. you would? 1. During the Reconstruction Period, why was there a struggle between theLegislative and Executive branches? Give an example of this struggle. What is the purpose of a rain gauge? a. to measure the amount of rainfall b. to predict how much rain is going to fall c. to predict whether or not it is going to rain d. to measure the temperature of the rain please select the best answer from the choices provided a b c d Explain how three major cultural changes taking place over the last 10,000 years have increased our overall environmental impact. What would a sustainability revolution involve? In what way did spas contribute to the growth of the tourism industry When two asset accounts are changed in a transaction, there must be an increase and a decrease. True or false?. k) pq (r + 1) - r (p + q)